t(11;18)(q21;q21) is the most common translocation in MALT lymphomas
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چکیده
منابع مشابه
t(11;18)(q21;q21) is the most common translocation in MALT lymphomas.
BACKGROUND Low grade malignant lymphomas arising from mucosa associated lymphoid tissue (MALT) represent a distinct clinicopathological entity. The cytogenetic findings and molecular genetics of MALT lymphomas remain minimally defined. Cytogenetic studies infrequently constitute part of the diagnostic work-up of MALT lymphomas, most commonly due to small biopsy size and their extranodal localiz...
متن کاملThe t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not.
In a recent issue of Blood, Murga Penas et al identified a novel cluster region on MALT1 from t(14;18)(q32;q21) IGH-MALT1 translocations in MALT lymphomas, which bears many similarities to the bcl-1 major translocation cluster (MTC) from mantle cell lymphomas and the bcl-2 major breakpoint region (MBR) from follicular and diffuse large B-cell lymphomas.1 We have previously reported that pro-B/p...
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متن کاملNon-MALT marginal zone lymphomas.
The concept of marginal zone B-cell lymphomas was developed in the 1990s for lymphomas whose cells originate from B lymphocytes normally present in a distinct anatomical location, the so-called ‘marginal zone’ (MZ). MZ has been described in the lymphoid organs—spleen and lymph nodes—and in nonlymphoid organs—mucosa-associated lymphoid tissue (MALT) or non-mucosal tissue such as skin, orbit and ...
متن کاملThe management of nongastric MALT lymphomas.
The group of marginal zone B-cell lymphomas (MZL) comprises three different entities, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (currently called MALT lymphoma), nodal marginal zone B-cell lymphoma (previously known as monocytoid lymphoma), and splenic marginal zone B-cell lymphoma (with or without circulating villous lymphocytes).[1-3] Primary splenic and no...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1997
ISSN: 0923-7534
DOI: 10.1023/a:1008202303666