t(11;18)(q21;q21) is the most common translocation in MALT lymphomas

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t(11;18)(q21;q21) is the most common translocation in MALT lymphomas.

BACKGROUND Low grade malignant lymphomas arising from mucosa associated lymphoid tissue (MALT) represent a distinct clinicopathological entity. The cytogenetic findings and molecular genetics of MALT lymphomas remain minimally defined. Cytogenetic studies infrequently constitute part of the diagnostic work-up of MALT lymphomas, most commonly due to small biopsy size and their extranodal localiz...

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The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not.

In a recent issue of Blood, Murga Penas et al identified a novel cluster region on MALT1 from t(14;18)(q32;q21) IGH-MALT1 translocations in MALT lymphomas, which bears many similarities to the bcl-1 major translocation cluster (MTC) from mantle cell lymphomas and the bcl-2 major breakpoint region (MBR) from follicular and diffuse large B-cell lymphomas.1 We have previously reported that pro-B/p...

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Hypersensitivity to House Dust Mite and Cockroach Is the Most Common Allergy in North of Iran

Background: Asthma and allergic rhinitis are among the most common diseases in the world. Objective: The aim of this study was to detect, by skin prick test, aeroallergens in allergic patients in Sari, Mazandaran in north of Iran. Methods: This is a prospective study of skin prick test of aeroallergens in asthma, allergic rhinitis and their combination with clinical diagnosis. Three hundred and...

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Non-MALT marginal zone lymphomas.

The concept of marginal zone B-cell lymphomas was developed in the 1990s for lymphomas whose cells originate from B lymphocytes normally present in a distinct anatomical location, the so-called ‘marginal zone’ (MZ). MZ has been described in the lymphoid organs—spleen and lymph nodes—and in nonlymphoid organs—mucosa-associated lymphoid tissue (MALT) or non-mucosal tissue such as skin, orbit and ...

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The management of nongastric MALT lymphomas.

The group of marginal zone B-cell lymphomas (MZL) comprises three different entities, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (currently called MALT lymphoma), nodal marginal zone B-cell lymphoma (previously known as monocytoid lymphoma), and splenic marginal zone B-cell lymphoma (with or without circulating villous lymphocytes).[1-3] Primary splenic and no...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 1997

ISSN: 0923-7534

DOI: 10.1023/a:1008202303666